This is amazing, to hear about the anterior mid-cingulate cortex. I suffered with severe depression for a few years after my parent’s death , desperate, a good friend of mine told me, you have to do exactly the opposite of what your brain (negative voice), is telling you to do. And so, I began doing it, the opposite: getting out of my bed, going outside, working out, working, eating healthy enough, spending time with people… without even noticing, a few months later , I was slowly going back to being myself. Without medication I still feel the sadness that caused my depression but decided to go live life . Great episode . Digging deeper with the footnotes. I am not going back to depression .